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It is a case of correlation in a multi-treatment protocol being misattributed to a single component

Matrix metalloproteinases (MMPs), alongside plasmin (derived from plasminogen released by fibroblasts and keratinocytes), are proteases that degrade collagen, elastin, and other ECM components, leading to dermal disorganization and destruction of the DEJ

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It is recommended to add a variety of foods rich in vitamin B12 and foods rich in folic acid